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The fact that elevated p16 level and SA--gal activity often precede the renal changes in different stages of CKD and CKD-related renal diseases (Li and Wang, 2018), p21 level is significantly up-regulated in human transplanted kidney undergoing AKI-to-CKD transition (Megyesi et al., 1999), suggesting that renal senescence is involved in the pathogenesis and progression of CKD

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Funding This work was supported by the China Agriculture Research System (CARS-47-G18) and Guangdong MEPP Fund (NO.2018C001) and the key research and development program in important fields of Guangdong Province (2019B020217001) to Professor Anxing Li

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