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For instance, reduced mtDNA copy number in subcutaneous adipose tissue is a well-documented feature of the lipoatrophy caused by older NRTIs like stavudine (d4T) and zidovudine (AZT), as mtDNA depletion impairs adipocyte differentiation and triglyceride storage

Second, the therapeutic effect of LNPG was shown both in vivo and ex vivo , when it was delivered to endothelial cells lacking a glycocalyx (137)

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