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However, this changes the pharmacokinetic profile and should be discussed with a healthcare provider before attempting

The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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Like it's all extrapolated off of rats

When considering supplementation that has not been specifically recommended by a healthcare professional whilst on any other medication, make sure you check with them beforehand to prevent any unexpected interactions