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Moriguchi et al., 2019), a major strength of the multimodal neuroimaging approach of TIGER is that it allows us to integrate information from multiple neuroimaging modalities (e.g., fMRI, diffusion MRI) to enable us to reconcile these potential discrepancies in the literature and gain a more precise understanding of glutamatergic abnormalities underlying MDD (Salvadore and Zarate, 2010

By molecular simulation, we have previously shown that YMU1 acts on the catalytic pocket of TMPK, which causes the expulsion of the lid domain to give an open conformation that inhibits the catalytic process 19

Another strategy to extend levodopa efficacy involves inhibiting catechol-O-methyltransferase, an enzyme responsible for both peripheral levodopa degradation and central dopamine breakdown

It stimulates glucose uptake, increases fat metabolism, and boosts mitochondrial function

After that, pertinent research has progressively surfaced [94]

(1975) Erythrocyte 2,3-diphosphoglycerate as related to diabetes and obesity