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doi: 10.3390/nu16142300 165 SharkeyK

Listed among absolute contraindications were the following (in no specific order): History of hormone-sensitive cancer (to include endometrial, breast, cervical, and prostate cancer) Current alcohol or drug use/abuse Liver insufficiency or cirrhosis Uncontrolled preexisting chronic medical conditions (including diabetes and hypertension) Preexisting history of ischemic cardiovascular or cerebrovascular conditions Severe psychiatric disorders influencing decision-making capacity Known noncompliance with previous medical treatment therapy Ask yourself

Additionally, enhanced enzymatic cross-linking of collagen might also play a role [69] as well as noncollagenous extracellular matrix (ECM) components (e.g., glycoproteins, elastin) which may reduce energy loss and help recover stored energy [70]

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This complexity complicates the development of precise and effective therapies that can specifically modulate ferroptosis without disrupting other essential cellular processes

A., Polverini, P