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These alterations often present as modified membrane protein activity, phospholipid asymmetry, or aberrant expression of adhesion molecules, ultimately resulting in compromised deformability, hemolysis, and pathogenic interactions with the vasculature (1216)

Clinically, GABA and GABA analogs have been investigated as potential analgesics in CIPN and other conditions (Zarba et al., 2020) because GABAergic neurons and receptors are involved in coordination of the perception and response to noxious stimuli (Mullins et al., 2014) might help direct the development and optimization of non-invasive interventions to maximize GABAergic signaling through endogenous mechanisms

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And I felt it once more in 2024, when I began to look after General, a cat with stage 4 CKD