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Injury Prevention: Strengthened connective tissues like tendons and ligaments protect the skeletal muscle from excessive strain

Wallis et al., 2007

38,238,243 Besides, the oscillation activation of SIRT1 also regulates the circadian dynamics via deacetylation of the core clock repressor PER2 K680 and mixed-lineage leukemia 1 (MLL1), thereby controlling rhythmic chromatin property and the activity of BMAL1: CLOCK complex

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Unlike peptides synthesized through traditional cellular pathways, MOTS-c originates from a unique source and exerts its influence through a powerful metabolic pathway, establishing a new paradigm in cellular communication and regulation