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Pro-inflammatory cytokines such as TNF-, IL-1, and IFN- activate NF-B and STAT-1 and 3 pathways, leading to the upregulation of Smad-7 expression (215, 216)

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The loss of TRAF6 binding of the LMP1 mutant V 380 A could be related to a loss of surface contacts between the side chains of LMP1 V 380 and TRAF6 V 474