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All the above methods have been systematically validated

Giese TJ, Panteva MT, Chen H, York DM (2015) Multipolar ewald methods, 1: theory, accuracy, and performance

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[24] [25] For patients with confirmed pathological hypercortisolism (Cushing's syndrome), definitive treatment depends on etiology and may include transsphenoidal surgery for pituitary adenomas, adrenalectomy for adrenal tumors, or medical therapy

The panel cited the high rate of acute kidney injury (AKI) in patients assigned to the treatment group, which it said could potentially be attributed to ITCA 650