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Factors such as aging, persistent stress, poor nutrition, and exposure to environmental pollutants can cause these levels to dip

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These findings establish the ROS/GSK3/GPX4 axis as a key driver of CO-induced ferroptosis, but how this pathway intersects with other cell-death pathways remains to be clarified

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doi: 10.1016/j.biopha.2024.116547 208 DoddDSpitzerMHVan TreurenWMerrillBDHryckowianAJHigginbottomSKet al

Figure 3 Experimental studies conducted in cells and mouse models of cancer indicate that different Se compounds exert anticancer effects in cancer