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In peripheral tissues, BHB is oxidized into AcAc in the reverse reaction catalyzed by BDH1 (Newman and Verdin, 2017

Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung

Conclusion Over the years, melatonins properties unfolded as a circadian regulator, anti-inflammatory, anti-oxidant, immune modulator, iron chelator, and, lately, an anti-ferroptosis

These changes can cause a cascade of oxidative damage that can systemically make its way to the male reproductive system, thereby affecting fertility

However, depending on the conditions and origin of the contamination, those levels can vary considerably (Pietsch 2020)

doi: 10.1128/mBio.01691-19 138 ZhuZ.ZhouY