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[9] In fact, it has been shown that most disease causing mutations of G6PD occur near the NADP + structural site

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Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S

Focusing on FoxO3a within the cochlea could potentially represent a viable therapeutic strategy for addressing drug-induced ototoxicity (Liu and Tang 2017)

As its commonly put: Genetics load the gun, but environment pulls the trigger. Many people have slow COMT variants but are asymptomatic, especially if they have a low-stress lifestyle, great diet, or other compensatory genes