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For example, the biosynthesis of many lipid molecules requires NADPH, including the production of triacylglycerols, phospholipids, and steroids

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Onodera, J

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Stewart et al., 2014)

Rotenone blocks the electron transport chain complex I which in turn causes mitochondrial dysfunction via increased levels of Cyt-c, disruption of the mitochondrial membrane, and oxidative stress 38