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While AC6 expression increases PKA activity and SR Ca 2+ uptake (Tang et al., 2011), deletion of AC6 results in diminished PKA activity, phospholamban (PLB) phosphorylation, and decreased SR Ca +2 -ATPase activity 2a (SERCA2) affinity toward Ca +2 in failing hearts (Takahashi et al., 2006

Inclusion of alemtuzumab improved engraftment outcome in certain studies

These changes compromise intestinal barrier integrity, leading to a leaky gut that allows bacterial products to enter systemic circulation

FRET biosensors used to detect cAMP include PKA-, Epac-, and CNGC-based cAMP sensors

The sample was centrifuged at 20,000 g for 3 min and the top 80 l was transferred to a glass autosampler vial with 300 l insert and capped