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NF-B signaling and the NLRP3 inflammasome Chronic inflammation serves as the core driver of declining renal function following AKI and progression to CKD

These active components help reduce abnormal -syn aggregation, block its neurotoxic effects, inhibit the apoptosis of dopaminergic neurons in the substantia nigra, regulate microglial activation, reduce the release of pro-inflammatory factors such as TNF- and IL-1, enhance antioxidant defense systems (e.g., by upregulating the Nrf2/HO-1 pathway) to mitigate oxidative stress damage, and promote neuroregeneration and synaptic repair

Pericoronary adipose tissue can secrete adipokines and other vasoactive mediators and/or oxidative products that can directly alter the phenotypes of perivascular adipocytes

SarmaSSinghDSinghPKharePMangalPSinghSet alFinger millet arabinoxylan protects mice from high-fat diet induced lipid derangements, inflammation, endotoxemia and gut bacterial dysbiosis

10.1038/s41398-023-02307-7 Transl