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The size, shape, and deformability of erythrocytes are crucial to their function, and abnormalities in these traits are seen in conditions like rheumatoid arthritis and T2DM

An imbalance between cellular oxidative and antioxidant systems, along with accumulation of oxidative damage and downregulation of Bcl2, can reduce the anti-apoptotic capacity of melanocytes, ultimately leading to hair greying [162]

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Sirtuin 3 has the capacity to catalyze the deacetylation of mitochondrial SOD2, which in turn increases the scavenging efficiency of O 2 in mitochondria

Similarly, the flavonoid calycosin, which also possesses antioxidant and anti-inflammatory properties, prevents high glucose-induced cell ferroptotic damage by upregulating the GSH/GPX4 pathway in human renal proximal tubular epithelial cells (HK-2 cells), reducing LPO, and inhibiting the expression of nuclear receptor coactivator 4 (NCOA4) (141)

While European nations set permitted thresholds for inorganic As at 0.15 mg/kg in polished rice [19,20,21]