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Five patients with newly diagnosed APL were intravenously administered at a dose of 0.16 mg/kg for 40 min infusion on the first day followed by 1820 h daily at a very slow rate with an infusion speed of 8 drips/min (Gao et al., 2018)

UK Kidney Association Clinical Practice Guideline: sodium-glucose co-transporter-2 (SGLT-2) inhibition in adults with kidney disease 2023 UPDATE

It is naturally produced in the liver and is crucial for detoxification, immune function, and combating oxidative stress

A careful risk/benefit evaluation must therefore be performed when planning the enrollment of children, especially before widespread clinical application [314]

Denning DW

Therefore, the inhibitors developed for the C467 residue of ASCT2 boast the advantages of high specificity and high potency, which can effectively avoid the loss of competitive inhibition by substrate analog inhibitors due to high substrate concentration