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Undas A, Pera-Kajn J, Gowacki R

The molecular interactomes that underpin pressure-sensitive and insensitive aspects of POAG remain to be fully characterized with potential clues from recent genome-wide association study (GWAS) analyses of adult-onset POAG loci including genes that encode cholesterol-binding caveolin proteins CAV1/2, ABCA1 (ATP-binding cassette transporter 1), TGFBR3 (transforming growth factor beta receptor 3), FOXC1 (forkhead box C1), ELOVL5 (elongation of long chain fatty acids family member 5), ATOH7 (atonal homolog 7), CYP1B1 (a cytochrome P450 enzyme) and ATXN2 (ataxin isoform 2) proteins

Our results indicate that protein degradation pathways are instead used to cope with internalized aggregates and can be neuroprotective for some amount of time

Although the biological effects mediated by EGCG were more similar to those of GTE in many parts of our analysis, our results indicated that CAT tested at the equivalent dose of EGCG can induce unique metabolic responses in HF mice

ANOVA followed by the Tukey post test)

The gene has approximately 2000 known mutations and all of them affect in some degree the protein function, which makes the pathophysiological manifestations to be multisystemic, mainly affecting the respiratory, gastrointestinal, endocrine, and reproductive tracts