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Several inherited peroxisomal disorders have been associated with severe neurologic dysfunctions, including hypotonia, seizures, cerebellar ataxia, sensory impairment, and developmental deficits 78

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In addition, the median time to onset of any-grade hepatic events (29.0 d), diarrhea/colitis (18.0 d), dermatitis/rash (24.0 d), and endocrine events (57.0 d) for participants who received STRIDE in our study differed when compared with the phase I/II multicohort CheckMate040 study (NCT01658878), which assessed multiple doses of nivolumab plus ipilimumab and reported an approximate median time to onset of hepatitis (39.256.7 d), diarrhea/colitis (58.8172.2 d), rash events (14.7135.8 d), and endocrine events (hyperthyroid events, hypophysitis, and hypothyroid events

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