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23 ) orthotopic patient-derived xenografts of IDH-mutant glioma to continuous infusions of amide- 15 N-glutamine, 15 N 2 -uridine or saline and performed conventional and spatial metabolomics on brain tissues (Fig

0%, P=0.030)

To test this, we first developed an acute hyperuricemia mouse model by injecting uric acid intraperitoneally to rapidly elevate blood UA levels

Ipamorelin (IPA) is also a synthetic peptide product that tends to be used solely for growth hormone (GH) release

The efficacy of different treatments was evaluated based on their ability to prevent overall and severe neurotoxicity

Signal Transduct Target Ther 6:94