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Following activation by redox signaling downstream of the MAPK signal pathway, the EpRE binding protein, also an oxidative stress-associated transcription factor, induces the dissociation of Nrf2 from Keap1 via redox modification and/or phosphorylation of Nrf2

Another meta-analysis (8 trials and 761 patients) similarly reported that melatonin as an adjuvant treatment for solid tumor cancers substantially improved tumor remission, 1-year survival, neurotoxicity, and fatigue and alleviated radiochemotherapy-related side effects [55]

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Jin, X., Yang, X., Islam, E., Liu, D