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SKU: 6253215762 · From condeoeiras.edu.pt

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Description

Toxicities induced in cultured human hepatocarcinoma cells exposed to ochratoxin A: oxidative stress and apoptosis status

The perfusion process also limits cellular uptake of heavy metal ions which are also known to further exaggerate oxidative stress via a Fenton-type reaction 11

Animal studies suggest that cochlear synaptopathydefined as the loss of synapses between IHCs and auditory nerve fibersmay contribute specifically to central auditory hyperactivity and tinnitus following noise exposure 41

Englert C, Trutzschler AK, Raasch M, Bus T, Borchers P, Mosig AS, et al

Hoxhaj G, Manning BD

Such changes are likely to alter the transmission of information in the ascending auditory pathway, and presumably contribute to altered perception of sounds that are independent of peripheral changes in thresholds