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Muscle Relaxants Hydrocodone bitartrate may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression

doi: 10.1155/2017/8130796

Microscopically, transmural hyperemia of the gastrointestinal tract, intestinal mucosa villi reduction, crypt reduction with focal denudation of superficial epithelia, and large bowel dilatation were all inhibited

Maffei M, Giordano A

In addition, the molecule itself has physicochemical shortcomings that pose challenges, including poor bioavailability, limited stability, and dose-limiting side effects 56