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Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

10,23,25 One cross-sectional study involving a cohort of patients with diverse causes of CKD showed that increased HIF pathway activity in the glomerular compartment was more common in patients with nephrosclerosis and was associated with decreased estimated glomerular filtration rate

In cancer cells, increased lactate concentrations have been reported to suppress apoptosis through HIF-1-mediated upregulation of anti-apoptotic proteins, including BCL-2 and survivin, while concurrently promoting ferroptosis resistance via SCD1 upregulation (58,141)

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Implications of dietary intervention for other diseases Dietary interventions may induce, prevent or delay the progression of various diseases in addition to cancer, which also influence human health and longevity

Physical therapy remains essential throughout recovery, directing newly formed tissue along functional stress lines and preventing the premature loading that causes most setbacks