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In addition, DIM may activate Nrf2, a key cellular signaling pathway that regulates antioxidant activity and detoxification

Gene expression analysis showed that a cluster of SlGSTU 24, SlGSTF 2, SlGSTZ 2, SlDHAR 2, SlEF1B 1, SlEF1B 3, and SlMGST genes expressed constitutively at all the analyzed tissues and developmental stages of tomato (Fig 5)

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Cell 184 , 12991313.e1219 (2021)

Jiyah A, Muhammad SA, Ibrahim A, Bulama I, Ibrahim A, Abbas AY, et al

Stromal interaction molecule 1 (STIM1) detects ER calcium depletion, translocates to ER-plasma membrane junctions, and activates Ca 2+ release-activated channels (CRAC) by tethering Orai proteins, triggering CaMKK activation, which phosphorylates AMPK at Thr172