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However, the clinical outcomes associated with deferiprone, an oral iron chelator, have been inconsistent

Next, we investigated the effect of long-term low v-ATPase deficiency on cytosolic pH, given that alterations in cytosolic pH homeostasis can have significant consequences for mitochondrial functionand vice versa

These metabolic improvements occurred alongside increased phosphorylation of insulin receptor substrate and Akt, key signaling molecules in the insulin/IGF-1 pathway

Mobilization of lysosomal-related vesicles into the axon is dependent on proper coupling of the adapter system that includes the BORC complex, the small GTPase Arl8b, and the adapter protein SKIP, which mediates coupling of lysosomes to kinesin-1 [51]