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Research has shown that A oligomers can induce IGF-1 resistance and IRS-1 inactivation, inhibit the PI3K/Akt pathway, and promote neuronal death, thereby leading to increased oligomeric A plaques and memory impairment [119, 175, 177]

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219 Similarly, -hydroxy -methyl butyrate, a leucine metabolite, exhibits protective properties

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Biochem Biophys Res Commun 289(1):161166

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Bibcode:1939NW.....27..850F

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