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Biomarker Context: When Oxidative Stress Assessment May Be Relevant Not all patients have elevated baseline oxidative stress, and not all benefit from antioxidant supplementation

[DOI] [PMC free article] [PubMed] [Google Scholar] [85].Sharma A, Yuen D, Huet O, Pickering R, Stefanovic N, Bernatchez P, de Haan JB, Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium

Additionally, proteolysis targeting chimeras (PROTACs) offer a novel approach to modulate ferroptosis: PROTACs targeting ACSL4 or Nrf2 have been developed to either induce ferroptosis (in renal cell carcinoma) or enhance antioxidant defense (in CKD), respectively, with improved specificity compared to small-molecule inhibitors

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The presence of high levels of VEGF-C and tumor lymphangiogenesis is associated with immunosuppression but might also indicate better efficacy for ICB treatment