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Uric acid therapy prevents early ischemic stroke progression: a Tertiary analysis of the URICO-ICTUS trial (Efficacy study of combined treatment with uric acid and r-tPA in acute ischemic stroke)

2022) is likely to be at least in part the consequence of a loss of astrocytic GSH and/or of alterations in the GSH metabolism of astrocytes

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451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig

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Moreover, it is reported that the increased glycolysis and oxygen consumption (118) is induced through the Akt/mTOR pathway (114)