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132 Additionally, diacyl polyunsaturated phosphatidylcholines (PC-PUFA2s) initiate lipid peroxidation through interactions with the mitochondrial ETC, which is correlated with cancer cell ferroptosis sensitivity

WWP2 deficiency may increase the activity of the tricarboxylic acid (TCA) cycle and mitochondrial respiratory metabolism, thereby improving RIF

Introduction into mammalian cells of the genes of various GSTs has produced some lines with modest levels of resistance to alkylating agents [47]

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However, these methods capture only a portion of the complexity of cellular regulation, as a substaintial fraction of human biology is governed at the proteome level through PTMs, which dynamically modulate protein structure, function and interactions in ways not captured by genetic approaches