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Acknowledgements This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (RS-2023-00245453)

TB-500's angiogenic activity provides a complementary mechanism vascular supply to injured tissue is required for repair, and in vitro data indicates TB-500 promotes endothelial tube formation through actin-polymerization modulation [6]

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10.1242/dmm.010736 68 LamA

In the cytosol, methylcobalamin becomes the cofactor for methionine synthase (encoded by MTR ), which remethylates homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate