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But previous studies have hypothesized oxidative stress as a common biochemical signature 26 and even shown some evidence in circulating serum redox proteins (e.g., myeloperoxidase) 59, 75 among LC patients

[6] Protein aggregation represents a major event of physical instability of proteins and occurs due to the inherent tendency to minimize the thermodynamically unfavorable interaction between the solvent and hydrophobic protein residues

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The reduction of NOx urinary excretion and the high concentration of nitrotyrosine in the rats plasma and organs exhibited that an interaction between nitric oxide (NO) and ROS could contribute to the pathogenesis of hypertension in BSO-treated rats (Eiserich et al., 1995)

Uric acid (UA), historically primarily linked to gout, has garnered increasing attention in the realm of neurodegenerative diseases due to its potential neuroprotective properties and emerging roles in mitigating oxidative stress and neuroinflammation [6]

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