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The activation of MMPs contributes to BBB impairment by degrading the perivascular basal lamina and proteins associated with tight junctions [65]

Conclusions and prospects Undoubtedly, as the most common probiotics, Lactobacillus played a vital role in maintaining the ecological balance of intestinal flora since it exerted excellent anti-inflammatory effects in IBD and IBD-related intestinal diseases such as CAC, as well as CNS diseases and liver diseases represented by AD, PD, and AIH, in both mouse model and clinical patients ranging from children to adults

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Most of them are constrained during zinc deficiency [12, 142]

doi: 10.1039/c8np00003d 44 LoceyM

In mice, administration of AgNPs and Ag nanowires (0.5 and 2.5 mg/kg) for 14 days reduced gut microbial diversity and altered community structure