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Thirdly, MDSCs can express and secrete VEGF, IL-1/2/10, TGF-, PDL 1/2, inducible nitric oxide synthase (iNOS), indoleamine 2,3-dioxygenase (IDO), and arginase-1 (ARG-1), which could recruit immunosuppressive cells and induce tumor immune evasion (162, 163)

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Curcumin as a steroid-sparing agent is another area of research, such as the use of lower doses of steroids in OLP or OSF when curcumin is concurrently administered, to evaluate whether this reduces steroid side effects while maintaining efficacy

In the FVB/N-TgN(v-Ha- ras )Led (Tg.AC) hemizygous male and female mice, histopathology did not show cell proliferation or hyperplasia in any of the tissues evaluated