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These observations highlight the need for large-scale, multicenter, randomized, placebo-controlled trials to ascertain whether targeted modulation of specific probiotic strains or other gut microbes associated with a lean phenotype can effectively counteract obesity and improve insulin sensitivity

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doi: 10.3389/fmars.2025.1636760 Received 29 May 2025 Accepted 07 July 2025 Published 31 July 2025 Volume 12 - 2025 Edited by Rachel Ann Hauser-Davis, Oswaldo Cruz Foundation (Fiocruz), Brazil Reviewed by Verdiana Vellani, University of Trieste, Italy Kamalesh Sen, University of Burdwan, India Updates Copyright 2025 Gora, Sreeram, Rehman, Ain, Chakraborty, Prema, Lavanya, Siriyappagouder and Asha

Byrav DSP, Medhi B, Prakash A, Chakrabarti A, Vaiphei K, Khanduja KL (2013) Comparative evaluation of different doses of PPAR- agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats