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23 Supplementation of 1 mg daily is recommended for patients with specific risk factors (e.g., bariatric/gastric surgery patients, those with severe malnutrition, chronic alcohol use, chronic hemolytic anemia and conditions with high cell turnover, and use of antimetabolite medications such as methotrexate)

It should ideally be evaluated alongside CJC-1295

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The Orange Book serves as an authoritative resource for healthcare providers, pharmacists, and industry professionals, supporting safe and effective drug substitution, compliance with regulatory requirements, and informed decision-making in drug prescribing and dispensing