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To investigate the role of ferrous iron, we assessed the relative content of ferrous iron in FAC and erastin treated IB3-1 CF and cognate C38 cells and found that the IB3-1 cells exhibited significantly increased levels of ferrous iron accumulation following FAC and erastin treatment, which was not apparent in C38 cells (Fig

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The number of mice in each group is shown in Supplementary Table S1

To test whether induction of ROS formation plays a role in starvation-induced organismal death in daf-12(rh61rh411) or din-1(dh127) mutants, worms were treated with N-acetylcysteine (NAC) (1 mM), a ROS scavenger 22

A randomized, multicenter, double-blind, placebo-controlled, dose-finding study of ORG 2766 in the prevention or delay of cisplatin-induced neuropathies in women with ovarian cancer