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Indeed, in the apolipoprotein E knockout model of atherogenesis, activation of Hcar2 on macrophages promotes cholesterol efflux and reduces atherosclerotic plaque burden [77]

The photoreceptors are the most superficial and they are the cells that are responsible for converting energy from the light from the outside world, into an electrical signal to be sent to the brain

doi:10.1017/s0007114521003007 Salek M, Clark CCT, Taghizadeh M, Jafarnejad S

Besides, two nitroimidazoles (Koike et al., 2020), itraconazole (Xu et al., 2021), and dichloroacetate (Sun et al., 2021) are also proven to have therapeutic potential through promoting ferroptosis in CSCs

Wu Y-L, Lin Z-J, Li C-C, Lin X, Shan S-K, Guo B, Zheng M-H, Li F, Yuan L-Q, Li Z

The enzyme is membrane-bound with its active site facing the external side of the cell