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FIGURE 1 Together, these elementsmechanism-based classification, PK/PD and biomarker emphasis, explicit clinical and immunotherapy safety benchmarking, multi-omics-enabled translational pipeline, and One Health integrationdifferentiate this article from prior OSC reviews and provide a roadmap from mechanistic promise to clinically and ecologically responsible dual-action application

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When damage to mitochondria occurs, PINK1 accumulates on the mitochondrial membrane and initiates the process of mitophagy ( 7.3 Impaired mitochondrial quality control in lung diseases In an attempt to protect mitochondrial function from further damage, cells have signaling pathways to induce the arrest of an organelle and prevent its division

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