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Similarly, dexmedetomidine pretreatment attenuates myocardial I/R injury by activating the 2-adrenergic receptor, which inhibits mitophagy and reduces injury [128] Thyroid hormone treatment also provides cardioprotection by enhancing PINK1-dependent mitophagy, reducing cell death, and preventing I/R injury [105]

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Anatomical data show that the ventral portion of the dentate nucleus provides signals to the association areas in the cerebral cortex through the thalamus, suggesting that these pathways are crucial for higher-order cognitive functions [91]

Annu Rev Physiol 57:707736 Moncada S, Bolanos JP (2006) Nitric oxide, cell bioenergetics and neurodegeneration