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While debate persists regarding the optimal dietary pattern for PCOS, the Mediterranean diet (MD), characterized by its richness in unsaturated fats, low-glycemic-index carbohydrates, fiber, and antioxidants, has emerged as a promising therapeutic approach (100)

One of the biologically most active carotenoids against oxidative damage, lycopene, contains 11 conjugated double bonds and has been reported to have anticancer activities via regulation of oxidative enzymes such as cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), inhibitory effect on tumor growth and progression, triggering apoptosis, modulation of proteins involved in cell cycle regulation, reduction of the incidence of breast, liver, pancreatic and other cancers (Tang et al

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