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doi:10.1074/jbc.M111773200

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Here are key points about these regulations and guidelines: : Various countries have specific regulatory agencies overseeing cell-based therapies

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Disease-causing variants in the primary genes associated with low pyruvate dehydrogenase complex activity result in pyruvate dehydrogenase complex deficiency by interfering with pyruvate flux and energy production from carbohydrate oxidation with resultant lactic acidemia, hyperpyruvicemia, hyperalaninemia, and hyperprolinemia aggravated with consumption of carbohydrate