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EDS patients also typically need pain management support for chronic pain symptoms, and they can face mental health complications like associated depression as well

In the oxidant recovery assay both mitochondrial sensors behaved like the cytosolic sensorfollowing diamide washout they recovered rapidly to the respective steady states with similar kinetics (Figure 2B)

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Best published PK (Awosemo et al., 2021, rats): ~38% oral bioavailability, ~6 to 7 hr oral half-life

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On the other hand, H 2 O 2 with its stability and long half-life can reach virtually any site and distribute its toxic effect all over the cell