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Further, the loss of Hb by use of a novel T-lymphocyte-specific Hb knock-out mouse impairs mitochondrial function, dysregulates cytokine production, and lowers the activation threshold primarily in CD4 + T-lymphocytes, indicating a critical role for Hb within this subset

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Future studies should focus not only on the antioxidative and immunomodulatory effects of NAC, but also on critically assessing how these properties translate to in vivo systems

5.4.1 CRISPR/dCas9-based methylation manipulation Innovative studies utilizing CRISPR/dCas9-TET1 systems for targeted DNA demethylation have provided direct evidence for the causal role of DNA methylation in EED-induced reproductive dysfunction