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12 May 2017

News in brief BioWorld Asia BioWorld Asia briefs for July 21, 2026 KBN-2201 reverses key features of Alzheimers in mice BioWorld Science Researchers from Ajou University School of Medicine reported the preclinical efficacy of KBN-2201 in a mouse model of late-stage Alzheimers disease

Inspired by this idea long acting dual agonists were developed to treat type 2 diabetes and several obesity related health issues

A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

Protein plus fast carbs works perfectly

Week 3-12: Increase to 100-150 mg daily if well-tolerated