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Journal of Peptide Research

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Fluorescence was measured at 4, 24, 48 and 72 h after treatment at 485 nm excitation and 530 nm emission on a SpectraMax M3 microplate reader (Molecular Devices)

[] This PDK-mediated inhibition of pyruvate dehydrogenase shifts mitochondrial metabolism toward reduced glucose oxidation and increased uncoupled glycolysis, promoting RV fibroblasts (RVfib) proliferation, collagen production, and ultimately right ventricular fibrosis and failure

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