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Inflammation from lupus puts you at increased risk of cardiovascular disease, says Lisa Criscione-Schreiber, MD, associate professor of medicine and rheumatology training and program director chair for the Program for Women in Internal Medicine in the Duke Department of Medicine in Durham, North Carolina

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Another mechanism involves activating death receptors of TNFR superfamily expressed on target cells, which binds procaspase-8 after activation of their ligands on NK cells, allowing its activation and triggering apoptotic pathways