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Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

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This can lead to a deficiency in vitamin B12 levels, for instance, which can lead to a number of health issues

To correct this, people often start taking supplements, sometimes in large doses

Barnett AH

Methylcobalamin B12 is considered very safe as a water-soluble vitamin