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Glossary 5-HT 5-Hydroxytryptamine 6-OHDA 6-Hydroxydopamine hydrobromide A/R Anoxia/Reoxygenation ACSL4 Acyl-CoA synthetase long-chain family member 4 AF4 Asymmetrical Flow Field-Flow Fractionation APP Amyloid precursor protein BDNF Brain derived neurotrophic factor BMP-2 Morphogenetic protein 2 CDK1/CDC2 Cyclin-dependent kinases 1/2 c-eEPSCs C-fiber evoked EPSCs CGRP Calcitonin gene-related peptide CIRI Cerebral ischemia-reperfusion injury COX2 Cyclooxygenase-2 DA Dopamine dRI Differential refractive index EPSCs Excitatory postsynaptic currents FPN1 Ferroportin 1 GABA -aminobutyric acid GE Gastrodia elata GSDMD Gasdermin D HBA p-Hydroxybenzyl alcohol HDL-C High cholesterol HPA Hypothalamic-pituitary-adrenal I/R Ischemia-reperfusion ICAM-1 Intercellular cell adhesion molecule-1 IDO 1 Indoleamine 1 ISVs Intersegmental vessels KA Kainic acid LDL-C Lipoprotein cholesterol LPS Lipopolysaccharide LTP Long-term potentiation MALS Multi-angle light scattering MAO-A Monoamine oxidase MCAO Middle cerebral artery occlusion MCP-1 Macrophage chemotactic protein-1 MDA Malondialdehyde MPO Myeloperoxidase MT1/2 Melatonin 1/Melatonin 2 NFATc1 Nuclear factor of activated T cells cytoplasmic 1 NFTs Neurofibrillary tangles NHBA N 6 -(4-hydroxybenzyl) adenine riboside NLRP3 NOD-like receptor thermal protein domain associated protein 3 NMDAR N-methy-D-aspartate receptors NSCs Neural stem cells NTG Nitroglycerin OCN Osteocalcin OGD/R Oxygen-glucose deprivation reperfusion ROS Reactive oxygen species SHR Spontaneously hypertensive rats TBI Traumatic brain injury TC High cholesterol TH Tyrosine hydroxylase TPH 2 Tryptophan hydroxylase 2 UCMS Unpredictable chronic mild stress Vanillin 4-hydroxy-3-methoxybenzaldehyde VCAM-1 Vascular Cell Adhesion Molecule 1 WGEW Water-soluble polysaccharide extracted from Gastrodia elata WSS25 A sulfated polysaccharide extracted from the rhizome of Gastrodia elata that binds to bone morphogenetic protein 2 References 1 Abdel-SalamO

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