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While the etiology of NTD is multifactorial, some studies have found that blood concentrations of homocysteine or holo-transcobalamin to be lower in NTD-affected infants and mothers compared to non-affected controls (reviewed in 59)

Ideal Candidates for Methylcobalamin vs

The role of the EAAT3 is to control glutamate spillover, which affects pre-synaptic N -methyl- D -aspartate (NMDA) and metabotropic glutamate receptors activity 63,64

However, research suggests that maintaining adequate B12 levels may help with weight management by improving energy levels[2] and overall metabolic efficiency[1], particularly for those with a deficiency

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In this case, clinicians are encouraged to start with the lowest therapeutic dose possible, carefully monitor its use in patients with infections, and ensure that the benefits exceed the risks (6)